Functional Animal Nutrition
25-Hydroxyvitamin D3 (or Calcifediol) is an endogenous Vitamin D metabolite, naturally produced in the liver of animals through hydroxylation of Vitamin D 3 (Cholecalciferol). It is the main circulatory Vitamin D in the blood stream before further conversion to Calcitriol, the ultimate bioactive hormonal form of Vitamin D in the kidney, that promotes the uptake of Calcium and Phosphorous in the intestine.
Suprema-D ® is a form of 25-Hydroxyvitamin D3 feed additive, stable under feed processing conditions, and 100% derived from plant source raw materials rather than from animal source. It is formulated for application in multivitamin mineral premixes, and complete feed, particularly for young animals, breeder animals, and layers. It is also beneficial for grower phase animals. Numerous animal studies suggest that Suprema-D® (25-Hydroxyvitamin D3) is 3 to 5x more bio-efficacious than standard Vitamin D3.
Suprema-D ® effectively makes up typical insufficiencies of Vitamin D3 in nutritional formulations, typically in gilt, sow, piglet, and layer diets. It significantly strengthens skeleton, bone health, and egg shell to bolster high reproduction, growth and laying performance. It permeates blood-placental barrier, hence effectively upholds bone growth in the critical fetal stage.
A metabolically stable analogue of N-acetylglutamate (NAG) that activates carbamyl phosphate synthetase (CPS) to accelerate urea cycle.
Supplementation of exogenous NCG to animals can boost endogenous Arginine synthesis and metabolism to produce NO (nitric oxide) and polyamines via urea circulation. Many studies demonstrated that NCG addition to feed is able to increase milk yield and quality, promote calves’ growth performance, improve meat quality & slaughter yield. It also strengthens heat stress tolerance, and its ability to boost sow’s reproductivity, promote growth of piglets and growing pigs, and improve meat quality.
Extracted metabolites of lactobacillus plantarum and etc., containing a kind of lasso-like microcin peptide (tertiary structure shown as below).
This endogenous peptide has a strong bacteriostatic and bacteriocidal effect against many standard and clinical strains of E. Coli and Salmonella with MIC and MBC shown below.
To E. Coli To Salmonella
MIC = 0.03-0.50μg/mL MIC = 0.03-0.06μg/mL
MBC= 0.25-2.00 μg/mL MBC= 0.125-0.250μg/mL
The composition is pH-stable, and thermostable.
A comprehensive piglet study demonstrated that Lactitide enabled better growth performance, lower inflammation level, healthier intestinal barrier, and more robust gut microflora than antibiotic treatment, with less than 1/10 dosage of antibiotic growth promotents.
An E. Coli and Salmonella challenge broiler study demonstrated that Lactitide exhibited strong efficacy in containing pathogenic infection, recovering villi/crypt structure, alleviating inflammation, resulting in improved growth performance versus antibiotic growth promotent treatment at less than 1/10 dosage.
Extracted metabolites of bacillus subtilis and etc., containing a 37-amino acid sublancin peptide (tertiary structure shown as below).
This endogenous peptide has a strong Bacteriostatic / Bacteriocidal effect against standard and clinical strains of clostridium perfringens and staphylococcus aureus with MIC and MBC shown below.
To staphylococcus aureus To clostridium perfringens
MIC = 1.3 μg/mL MIC = 0.8 μg/mL